• Scott Young

Breaking Down the 49ers 2021 Schedule






The San Francisco 49ers unveiled their schedule for the 2021 season as well as the opponents and dates for their preseason games.


Facing the NFC North and AFC South along with their NFC West rivals, the 49ers will also host the Atlanta Falcons and travel to face the Cincinnati Bengals and the Philadelphia Eagles.


Let’s break each game down.


Week 1 – Sunday, September 12 at Detroit – 10:00 a.m. PT on FOX


The 49ers open the season on the road for the third time in the last four seasons. While on paper the Lions are nothing to Goff at, this game will likely come down to how well Detroit can best incorporate their new signal caller.


Week 2 – Sunday, September 19 at Philadelphia – 10:00 a.m. PT on FOX


While this should be an easier game for the 49ers, we’ve seen a few times how mobile quarterbacks can frustrate the 49ers defense. With former defensive coordinator Robert Saleh now the head coach for the New York Jets, new defensive coordinator DeMeco Ryans will need to be on his game and in control of the defense early in the season to help ensure a win.


Week 3 – Sunday, September 26 vs. Green Bay Packers – 5:20 p.m. PT on NBC


The 49ers welcome fans back to Levi’s in the home opener against the Green Bay Packers in a prime time game. (The second time in three seasons) Who will be under center for the Packers? Will they be able to stop the Mosterati? Whatever the answers are it will be great to have fans back cheering on the Niners.


Week 4 – Sunday, October 3 vs. Seattle – 1:05 p.m. PT on FOX


The 49ers face their division rivals the earliest time in the season since they faced the Seahawks in week two in 2017. The Seahawks spent much of their offseason adding pass catchers, adding tight end Gerald Everett in free agency and drafting WR D'Wayne Eskridge with one of their three draft picks. This will be a big test for the thin depth in the 49ers secondary as well as the front in containing Russell Wilson.


Week 5 – Sunday, October 10 at Arizona – 1:25 p.m. PT on FOX


The 49ers have come out of their last two trips to Arizona with wins, and having back to back games against two division rivals will be tough. Containing QB Kyler Murray and severing the connection between him and WR DeAndre Hopkins will be key to making it three in a row.


Week 6 – Sunday, October 17 – BYE


Another early season bye week. This time in week six. This will be the first time since 2009 the 49ers had a bye week in week six.


Week 7 – Sunday, October 24 vs. Indianapolis – 5:20 p.m. PT on NBC


The 49ers have not won a game against the Colts since 2001. A prime time game and the Colts first regular season trip to Levi’s sets the 49ers up for a win.


Week 8 – Sunday, October 31 at Chicago – 10:00 a.m. PT on FOX


The Bears and the 49ers have a history of playing on Halloween, squaring off twice before, most recently on October 31st, 2004. An early morning game facing draft crush and former-protégé-of-Kyle Shanahan Justin Fields should make this an extra spooky affair.


Week 9 – Sunday, November 7 vs. Arizona – 1:25 p.m. PT on FOX


The 49ers have won seven of their last 12 home games against Arizona. This will be a big test for the 49ers as both teams will be coming into their own and figuring out what works for them.


Week 10 – Monday, November 15 vs. Los Angeles Rams – 5:15 p.m. PT on ESPN


The 49ers share a record with the Pittsburgh Steelers with most wins during Monday Night Football with 49 (!). If they want to make it to 50 they will need to contain new QB Matthew Stafford and force head coach Sean McVay to rely on their run game.


Week 11 – Sunday, November 21 at Jacksonville – 10:00 a.m. PT on FOX


Despite drafting QB Trevor Lawrence and running back Travis Etienne in the first round of this year’s NFL Draft, the Jaguars are nowhere close to being on the 49ers level.


Week 12 – Sunday, November 28 vs. Minnesota – 1:25 p.m. PT on FOX


The 49ers have won 10 of their last 11 home games against the Vikings, most recently beating them 27-10 in the 2019 divisional round of the playoffs.


Week 13 – Sunday, December 5 at Seattle – 5:20 p.m. PT on NBC


The 49ers face the Seahawks in another prime time game, their second in three seasons. They defeated Seattle in their last prime time game 26-21 on December 29th, 2019.


Week 14 – Sunday, December 12 at Cincinnati – 10:00 a.m. PT on CBS


The 49ers defense should be a major test for young QB Joe Burrow and newly drafted WR Ja’Marr Chase. If the connection is there and if Joe Mixon is healthy the game could be tougher than we may anticipate.


Week 15 – Sunday, December 19 vs. Atlanta – 1:05 p.m. PT on CBS


The 49ers are 1-1 against the Falcons at home, and with Shanahan’s knowledge of the personnel, proper game planning and execution by the 49ers will be imperative in making it 2-1.


Week 16 – Thursday, December 23 at Tennessee – 5:20 p.m. PT on NFLN


The 49ers will have their work cut out for them, travelling to Tennessee on a short week and having to face one of the most violent runners in the NFL in Derrick Henry. That early bye will come back to bite them as rest and recovery before and after this game will be that much more important.


Week 17 – Sunday, January 2 vs. Houston – 1:05 p.m. PT on CBS


The Texans will be making their first regular season appearance at Levi’s Stadium, and with the 49ers winning their last three of four regular season matches and with the uncertainty around who will be under center for the Texans, barring something major the 49ers should be able to change that record to four of their last five pretty easily.


Week 18 – Sunday, January 9 at Los Angeles Rams – 1:25 p.m. PT on FOX


The last meeting of the regular season against a division rival, this will likely come down to the health of both teams. With one extra game this season staying healthy will be that much more important in any team’s bid for a postseason run.



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