San Francisco-Indianapolis: 49ers open as two-point road underdogs

The San Francisco 49ers have fell to 0-4 on the season and head to the road to Indianapolis. The Colts are 1-3, coming off a loss against the Seahawks on the road.

The 49ers have lost their last three games by a combined eight points. San Francisco is 3-1 ATS, while the Colts are 2-2 ATS. Below is the spread, over/under and moneyline for this weekend against the Colts.

Spread: San Francisco +2

O/U: 43 points

Moneyline: San Francisco +105, Indianapolis -125

I think Indianapolis covers this spread. Two points is always really tight, but I think the Colts end up winning a three or four-point game. I would hit the under and take the Colts on the moneyline.

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